Jinlong Ru
Computational Biologist
Jinlong Ru
Computational Biologist
Postdoctoral Researcher
Technical University of Munich (TUM) & Helmholtz Zentrum MΓΌnchen
Research Focus: Viromics, Phage Therapy, Metagenomics
About Me
I am a computational biologist specializing in the analysis of viral metagenomes and bacteriophage-host interactions. My research combines bioinformatics, systems biology, and microbiology to develop computational tools for discovering novel therapeutic phages and understanding viral ecology.
Expertise: Metagenomics, Bioinformatics, Phage Biology, Systems Pharmacology
Research Areas
π¬ Viromics & Phage Discovery
Novel bacteriophage identification from metagenomic datasets
π» Computational Tool Development
Bioinformatics pipelines for viral metagenome analysis
π¦ Phage-Host Dynamics
Molecular mechanisms of phage-bacteria interactions
Current Projects
PVP Compendium Project
Goal: Create a comprehensive database of phage-encoded viral-like particles (PVPs)
Status: Active development, preprint available on bioRxiv
Metagenomic Phage Discovery
Goal: Develop automated pipelines for identifying novel phages from environmental samples
Status: Ongoing optimization and validation
Selected Publications
Bacteria and Bacteriophage Consortia Are Associated with Protective Intestinal Metabolites in Patients Receiving Stem Cell Transplantation
Thiele Orberg, E., Meedt, E., Hiergeist, A., Xue, J., Heinrich, P., , et al. | Nature Cancer, 2024
Abstract: This study identifies a microbiome signature associated with protective immunomodulatory metabolites and provides a rationale for considering metabolite-producing consortia as microbiome-based therapies in stem cell transplantation. Read Paper β
Helicobacter pylori Infection Alters Gut Virome by Expanding Temperate Phages Linked to Increased Risk of Colorectal Cancer
Luo, S., , Khan Mirzaei, M., et al. | Gut, 2024
Abstract: This research demonstrates that H. pylori infection expands temperate phages in the gut, potentially contributing to colorectal cancer development through virus-bacteria interactions. Read Paper β
Unveiling the Hidden Role of Aquatic Viruses in Hydrocarbon Pollution Bioremediation
, Xue, J., Sun, J., et al. | Journal of Hazardous Materials, 2023
Abstract: This study reveals that aquatic viruses encode hydrocarbon degradation genes, suggesting their potential role in environmental bioremediation and highlighting the under-characterized global virosphere. Read Paper β
ViroProfiler: A Containerized Bioinformatics Pipeline for Viral Metagenomic Data Analysis
, Khan Mirzaei, M., Xue, J., et al. | Gut Microbes, 2023
Abstract: ViroProfiler is a containerized bioinformatics workflow for analyzing viral metagenomic data, ensuring computational reproducibility and facilitating collaborative research in viromics. Read Paper β
Software & Tools
PVP-Miner
A tool for mining Phage-encoded viral-like particles from genomic data. GitHub β
TCM-Mesh
A comprehensive pharmacology platform for Traditional Chinese Medicine. Website β